Blar i forfatter "Åström, Pirjo"

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    • Evaluation Challenges in the validation of B7-H3 as oral tongue cancer prognosticator 

      Sieviläinen, Meri; Wirsing, Anna Maria; Hyytiäinen, Aini; Almahmoudi, Rabeia; Rodrigues, Priscila; Bjerkli, Inger-Heidi; Åström, Pirjo; Toppila‑Salmi, Sanna; Paavonen, Timo; Coletta, Ricardo D.; Hadler‑Olsen, Elin; Salo, Tuula; Al‑Samadi, Ahmed (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-21)
      B7-H3 was the only molecule identified with prognostic potential from a recent systematic review of the prognostic value of immune checkpoints in oral cancer. We aimed to validate this finding in a multicenter international cohort. We retrospectively retrieved 323 oral tongue squamous cell carcinoma (OTSCC) samples from three different countries (Brazil, Finland, and Norway) for immunostaining and ...

    • The interplay of matrix metalloproteinase-8, transforming growth factor-β1 and vascular endothelial growth factor-C cooperatively contributes to the aggressiveness of oral tongue squamous cell carcinoma 

      Åström, Pirjo; Juurikka, Krista; Hadler-Olsen, Elin Synnøve; Svineng, Gunbjørg; Cervigne, Nilva K.; Coletta, Ricardo D.; Risteli, Juha; Kauppila, Joonas H.; Skarp, Sini; Kuttner, Samuel; Oteiza, Ana; Sutinen, Meeri; Salo, Tuula (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-08-03)
      Background: Matrix metalloproteinase-8 (MMP-8) has oncosuppressive properties in various cancers. We attempted to assess MMP-8 function in oral tongue squamous cell carcinoma (OTSCC).<p> <p>Methods: MMP-8 overexpressing OTSCC cells were used to study the effect of MMP-8 on proliferation, apoptosis, migration, invasion and gene and protein expression. Moreover, MMP-8 functions were assessed in the ...

    • Tumour cells express functional lymphatic endothelium-specific hyaluronan receptor in vitro and in vivo: Lymphatic mimicry promotes oral oncogenesis? 

      Karinen, Sini; Juurikka, Krista; Hujanen, Roosa; Whabi, Wafa; Hadler-Olsen, Elin Synnøve; Svineng, Gunbjørg; Eklund, Kari K.; Salo, Tuula; Åström, Pirjo; Salem, Abdelhakim (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-03-05)
      Lymphatic metastasis represents the main route of tumour cell dissemination in oral squamous cell carcinoma (OSCC). Yet, there are no FDA-approved therapeutics targeting cancer-related lymphangiogenesis to date. The lymphatic vessel endothelial hyaluronic acid receptor 1 (LYVE-1), a specific lymphatic marker, is associated with poor survival in OSCC patients. In this study, we present a potential ...